Table 7. Overlapping genes between hepatocellular adenoma induced by DEN/500 ppm PB in C3H mice and livers in CD-1 mice treated with 2500 ppm PB for 7 days: detailed information of genes with gene ontology terms of relationship to CAR or beta-catenin and/or cell proliferation based on published references.
| C3H mice (up-regulated) |
Gene ontology terms of relationship to: |
Ref. | |||
| Gene symbol (mouse) | p-Value | Fold-change | CAR or beta-catenin | Cell proliferation or cell growth | |
| Abcc4 | 8.93 × 10–5 | 104.2 | Activation of CAR induces hepatic up-regulation of Abcc4 in a CAR-dependent manner. | Abcc4 enhances cell growth by progressing cell cycle. | 73 |
| 74 | |||||
| Cblb | 4.21 × 10–2 | 2.2 | — | Cblb regulates growth factor receptor signaling negatively and is involved in the inhibition of cancer cell proliferation. | 75 |
| Ccdc85b | 7.77 × 10–3 | 1.6 | Ccdc85b activates the degradation of beta-catenin. | Ccdc85b inhibits tumor cell growth. | 76 |
| Prg4 | 1.09 × 10–2 | 1.8 | Activation of Wnt/beta-catenin signaling increases Prg4 expression and slow-cell cycle population. | Prg4 suppresses synovial cell proliferation. | 77 |
| 78 | |||||
| Tff1 | 1.97 × 10–4 | 16.3 | Tff1 promotes invasion and chemoresistance in cancer through Wnt/beta-catenin signaling. | Tff1 reduces cell proliferation by delaying G1-S cell cycle transition. | 79 |
| 80 | |||||
| Gene symbol (mouse) | C3H mice (down-regulated) |
Gene ontology terms of relationship to: |
Ref. | ||
| p-Value | Fold-change | CAR or beta-catenin | Cell proliferation or cell growth | ||
| Apoa1 | 2.36 × 10–3 | –1.5 | Activation of CAR decreases plasma HDL level through down-regulation of Apoa1 expression. | Apoa1 promotes proliferation of human endothelial progenitor cells. | 81 |
| 82 | |||||
| Cdk5r1 | 2.43 × 10–2 | –1.2 | — | Cdk5r1 has a role of induction in beta-cell proliferation. | 83 |
| Dlg1 | 9.79 × 10–3 | –1.6 | Beta-catenin contributes to tumorigenesis through inducing DLG degradation (anti-Dlg1 antibody was used in this study). | Dlg1 is involved in inhibition of cell cycle progression by blocking G0/G1 transition. | 84 |
| 85 | |||||
| Egfr | 3.18 × 10–2 | –3.2 | Phenobarbital activates CAR by repressing the Egfr signaling. | Egfr signaling play key roles in hepatic cell proliferation. | 86 |
| 87 | |||||