Fig. 4. NP long term exposure caused mitochondrial dysfunction and oxidative stress of islet cells in the pancreas. (A) NP exposure increased the ROS levels of islet cells in the pancreas. (B) NP exposure up-regulated the levels of [Ca2+]i. (C) NP exposure decreased the levels of MMP in the islet cells in a dose-dependent manner. Results are expressed as mean ± SEM (n = 8) (*p < 0.05 indicated doses of NP treated groups vs. control group).
