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. 2017 Jan 23;6(2):162–172. doi: 10.1039/c6tx00428h

Table 8. Enriched KEGG pathways of arsenite-upregulated miRNA target genes.

Signaling pathway Target genes
MAPK DUSP8, MEF2C, MAP3 K1, MAP2 K3, SOS2, CRKL, DUSP6, FLNB, MAP3 K3, NRAS, PPP3CA, PRKX, TAOK1, RASA1, TGFBR2, MAP4 K4, RAPGEF2, EGFR, TAB2, FOS, KRAS, RAC1, RPS6KA3, MAP3 K14
PI3K-Akt PIK3R1, SOS2, IRS1, ITGB8, MDM2, NRAS, RPS6KB1, CREB3L2, EGFR, SGK3, KRAS, PKN2, RAC1, YWHAE, CCND2
Jak-STAT SPRY2, IL12A, PIK3R1, SOS2, STAT3, IFNGR2, CBL, SOCS5, CCND2
FoxO PIK3R1, SOS2, STAT3, MDM2, S1PR1, EGFR, SGK3, GABARAPL1, KRAS, SMAD2, CCND2
Cytokine–cytokine IL12A, CCL1, IFNGR2, TNFRSF11B, TGFBR2, TNFRSF10A, ACVR1B, ACVR2A, EGFR, IL17RB
Chemokine PIK3R1, CCL1, SOS2, STAT3, TIAM1, CRKL, NRAS, PRKX, PXN, KRAS, RAC1
TNF DNM1L, JAG1, PIK3R1, MAP2 K3, CREB3L2; CEBPB, TAB2, FOS, MAP3 K14
cAMP ATP2B4, PIK3R1, TIAM1, PRKX, CREB3L2, FOS, GNAS, RAC1
TGF-beta SMAD3, SMAD5, RPS6KB1, SKP1, TGFBR2, ACVR1B, ACVR2A, ZFYVE9
HIF-1α PIK3R1, STAT3, IFNGR2, RPS6KB1, EGFR, HIF1A
Toll-like receptor IL12A, PIK3R1, MAP2 K3, TAB2, FOS, RAC1
Inflammatory mediator regulation of TRP channels GNAS, PRKX, PIK3R1, MAP2 K3
p53 CCND2, MDM2