Scheme 1. Synthesis of hybrid 5. Conditions and reagents: (a) p-TSA, toluene, 120 °C, 8 h; (b) diphenylether, 220 °C, 2 h, after two steps 98%; (c) POCl₃, 110 °C, 2 h, 100%; (d) NH₂(CH₂)₅OH, pentan-1-ol, 150 °C, 24 h, 59%; (e) CBr₄, PPh₃, CH₂Cl₂, 0 °C – rt, 24 h, 41%; (f) 4-pyridinealdoxime, NaI, EtOH, 80 °C, 48 h, UHPLC, 14%.