Table 2. Synopsis of in vitro biological data and calculated octanol/water partition coefficients (log P).
Compound | IC50 RBC-AChE ± SEM a (μM) | log P | IC50 CHO-K1 ± SEM a (mM) | IC50 HepG2 ± SEM a (mM) |
5 | 2.47 ± 0.13 | –1.65 | 5.0 ± 0.7 | 1.21 ± 0.08 |
Pralidoxime | 217 ± 17 | –3.26 | 32.0 ± 3.4 | 23.59 ± 0.52 |
Obidoxime | 197 ± 8 | –6.93 | 12.0 ± 1.6 | 4.02 ± 0.28 |
7-MEOTA | 10.0 ± 1.0 | 0.66 | 0.063 ± 0.004 | 0.0115 ± 0.0003 |
4-PA | >100 | –0.51 | 15.8 ± 1.6 | 13.19 ± 1.47 |
aResults are expressed as the mean of at least two independent experiments.