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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Metabolism. 2018 Mar 26;85:116–125. doi: 10.1016/j.metabol.2018.03.017

Figure 2. Study diagram of the clinical study.

Figure 2

We divided the outline of the study in 2 portions (described in detail below): first inpatient stay (composed by inpatient admission prior to randomization and inpatient admission after randomization) and second (return) inpatient stay at week 24.

Inpatient Admission prior to randomization: Day 1: Screening interview including screening labs and informed consent

Day 3: DXA (dual energy X-ray absorptiometry)

Day 4: OGTT (oral glucose tolerance test)

Day 5: Whole room indirect calorimetry for the assessment of the 24h energy expenditure at baseline

Day 6-7-8: Assessment of ad libitum food intake with vending machine paradigm at baseline

Inpatient Admission after randomization: Day 9-10: Exenatide/Placebo injection education (subcutaneous)

Day 11: Whole room indirect calorimetry for the assessment of the 24h energy expenditure during Exenatide/Placebo

Day 12-13-14: Assessment of ad libitum food intake with vending machine paradigm during intervention period

Day 15: Lifestyle recommendations

After the first 2 weeks of inpatient visit, volunteers returned for weekly follow up visit up to 5 weeks, and then, for monthly follow up visits up to week 24

Return Inpatient Admission on week 24: Day 1: Screening interview including screening labs and informed consent

Day 3: DXA (dual energy X-ray absorptiometry)

Day 4: OGTT (oral glucose tolerance test)

Day 5: Whole room indirect calorimetry for the assessment of the 24h energy expenditure at baseline

Day 6-7-8: Assessment of ad libitum food intake with vending machine paradigm at baseline