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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Metabolism. 2018 May 9;85:240–249. doi: 10.1016/j.metabol.2018.05.003

Fig. 2. LH and FSH circulating levels on day 3 of isocaloric fed state [Fed], 72h complete fasting with placebo [Fa+Pl] or 72h complete fasting with metreleptin replacement [Fa+Lep]) [Study 1].

Fig. 2

LH is decreased during fasting (A), primarily in males (B) and less (non-significant) in females (C) treated with placebo. Leptin replacement prevents the decrease of LH (A–D). FSH does not change independent of treatment (fed, fasting+placebo or fasting+leptin) (E–H). (Trt [Type of Treatment, i.e. Fed, fasting+placebo or fasting+leptin], Time [hours starting from 8 am on day 3 till 6 am on day 4]). P-values were calculated with two-way ANOVA and post-hoc Tukey’s test was used to compare the three types of treatment (Fed, Fa+Pl, Fa+Lep). One-way analysis of variance (Friedman test for paired and Kruskal-Wallis test for unpaired measurements) followed by post-hoc Dunn’s test was used to compare the area under the curves (AUCs) of the three treatment groups.