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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Metabolism. 2018 May 9;85:240–249. doi: 10.1016/j.metabol.2018.05.003

Fig. 3. Testosterone circulating levels on day 3 of three different conditions (isocaloric fed state [Fed], 72h complete fasting with placebo treatment [Fa+Pl], 72h complete fasting with metreleptin replacement [Fa+Lep]) [Study 1].

Fig. 3

Testosterone is decreased during fasting (A), more robustly in males (B,D) than in females (C,D). Leptin replacement partially prevents the testosterone reduction during fasting (B,D) in males, while it has no effect on females (C,D). (Trt [Type of Treatment, i.e. Fed, fasting+placebo or fasting+leptin], Time [hours starting from 8 am on day 3 till 6 am on day 4]). P-values were calculated with two-way ANOVA and post-hoc Tukey’s test was used to compare the three types of treatment (Fed, Fa+Pl, Fa+Lep). One-way analysis of variance (Friedman test for paired and Kruskal-Wallis test for unpaired measurements) followed by post-hoc Dunn’s test was used to compare the fold-to-baseline AUCs of the three treatment group.