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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Clin Pharmacokinet. 2018 Sep;57(9):1059–1074. doi: 10.1007/s40262-018-0632-y

Figure 1. Factors affecting the pharmacokinetics and pharmacodynamics of drugs in central nervous system.

Figure 1

This figure demonstrates various factors the influence pharmacokinetic and pharmacodynamic activity in CNS and highlights various compartments of drug action. Effect of physicochemical properties, specific and non-specific protein binding and drug transporters are illustrated. Drug transporters along the membranes may also co-localize which leads to bidirectional movement of drugs. Legend: BBB – blood brain barrier, BCSFB – blood CSF barrier