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. 2018 Jul 26;9:2929. doi: 10.1038/s41467-018-05325-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Pathway analysis. The pathway proposed was deduced from in silico literature mining for functional interactions of the differentially methylated genes. The network was consolidated by verification of each interaction in the published literature. Hypermethylated genes are depicted in blue and hypomethylated genes are given in orange. Note that DLX1/DLX2 may influence MAPT either via the WNT (brown) or via the GABA signaling (green) pathway (for details see text)