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. 2018 Jul 26;9(8):817. doi: 10.1038/s41419-018-0788-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, c ESCC cell lines were treated with ACY-1215 for 48 h. Cells were then stained with propidium iodide, and analyzed by LSR II flow cytometer. ACY-1215 caused a significant increase in the G2/M phase and a decrease in the G1 phase, occurred in a dose-dependent manner. b, d Western blot analysis of G2/M phase cell cycle regulatory-proteins for 48 h