Fig. 6. Anti-miR-30d partially restored the G2/M arrest and apoptosis and AKT signaling caused by ACY-1215 treatment.

a, c The ACY-1215 (50 μM) induced G2/M phase cell cycle arrest was partially rescued by anti-miR-30d (50 nM). Cells were treated with Lipofectamine 2000, 50 μM ACY-1215, and/or 50 nM miR-30d inhibitor for 48 h. b, d The ACY-1215 (50 μM) induced apoptosis was partially rescued by anti-miR-30d (50 nM). Cells were treated with Lipofectamine 2000, 50 μM ACY-1215, and/or 50 nM miR-30d inhibitor for 48 h. The results are shown as the mean ± SD. **p < 0.01; ***p < 0.001