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. 2018 Jul 26;8:11269. doi: 10.1038/s41598-018-29620-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pairwise dN/dS of genes encoding human T cell epitopes and regulatory proteins in L5 and L6. Estimation of pairwise dN/dS of epitopes (a) and regulatory proteins (b) using the entire 147 L5 against the 67 L6 genomes. Estimation of pairwise dN/dS of epitopes (c) and regulatory proteins (d) using the mean dN/dS values of 10 random samples (size = 67, with replacement) of L5 against the 67 L6 genomes.