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. 2018 Jul 26;8:11295. doi: 10.1038/s41598-018-29618-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Study of payload delivery by Fe₃O₄-Au hybrid NPs. (a,b) Confocal intravital microscopy (IVM) of NRed-NP-Cy5 in superficial 4T1 tumor vessels upon i.v. injection to a mouse (6.6 mg·kg⁻¹ Fe₃O₄). (a) NRed-NP-Cy5 and particles aggregates (yellow) circulating in tumor vasculature (dashed lines). Cyan – neutrophils (Ly6G), green – Nile Red, red – Cy5. See also Supplementary Video S3. (b) Nile Red release into tumor tissues (arrow). Time lapsed imaging has been collected for 440 s. Blue – neutrophils (Ly6G), green – Nile Red, red – Cy5. See also Supplementary Video S4. (c) IVM of 4T1-GFP tumor (cyan) accumulating NRed-NP-Cy5 6 h after i.v. injection. Green – Nile Red, red – Cy5. (d) High magnification of the selected area from (c). (e) 4T1-GFP tumor from untreated animal, IVM.