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. 2018 Jul 26;9(8):818. doi: 10.1038/s41419-018-0848-7

Fig. 4. Pro-oxidant species contribute to α-syn-mediated activation of the DDR.

Fig. 4

a, b Administration of the antioxidant NAC mitigates formation of PFF-mediated γH2AX and 53BP1 foci in differentiated SH-SY5Y cells. c Administration of the nitric oxide donor nitrite, which activates the endogenous antioxidant Nrf2 pathway, reduces formation of PFF-mediated γH2AX foci. Scale bars: 50 μm. (*p < 0.05; **p < 0.01; ***p < 0.005; ****p < 0.001; one-way ANOVA followed by Dunnet’s multiple comparison post doc test.) All bar graphs show mean + /- s.e.m