Table 3.
Phenotype of validation group CSF BCL: secreted cytokine expression.
| Cytokine | Diagnostic category | Concentrations (pg/mL) mean SD median | F-test p | Pair-wise comparison | Tukey adjusted p | Difference between means (pg/mL) | ||
|---|---|---|---|---|---|---|---|---|
| IL-1β | HV+NIND | 22.6 | 22.6 | 13.9 | 0.0011 | HV+NIND vs. RRMS | 0.0031 | 14.4 |
| OIND | 13.9 | 10.8 | 10.3 | OIND vs. RRMS | 0.0434 | 5.7 | ||
| RRMS | 8.2 | 7.3 | 7.2 | RRMS vs. SPMS | 0.0377 | 5.3 | ||
| SPMS | 13.5 | 12.6 | 9.6 | RRMS vs. PPMS | 0.0111 | 6.1 | ||
| PPMS | 14.3 | 10.7 | 11.2 | RRMS vs. PMS | 0.0028 | 5.6 | ||
| PMS | 13.8 | 11.73 | 10.1 | |||||
| IL-6 | HV+NIND | 232.4 | 268.1 | 91.5 | 0.3774 | |||
| OIND | 172.6 | 278.5 | 62.2 | |||||
| RRMS | 107.8 | 141.1 | 72.8 | |||||
| SPMS | 143.1 | 240.3 | 55.0 | |||||
| PPMS | 195.6 | 294.0 | 82.1 | |||||
| PMS | 167.1 | 266.0 | 69.9 | |||||
| TNF-α | HV+NIND | 1099.9 | 1081.7 | 601.6 | 0.0044 | HV+NIND vs. PPMS | 0.0242 | −184.0 |
| OIND | 1000.4 | 604.9 | 865.5 | HV+NIND vs. PMS | 0.0217 | −117.0 | ||
| RRMS | 713.8 | 538.9 | 582.1 | RRMS vs. PPMS | 0.0193 | −570.1 | ||
| SPMS | 1160.5 | 876.1 | 904.8 | RRMS vs. PMS | 0.0122 | −503.1 | ||
| PPMS | 1283.9 | 686.7 | 1254.9 | |||||
| PMS | 1216.9 | 793.4 | 1039 | |||||
| GM-CSF | HV+NIND | 194.1 | 230.8 | 99.4 | 0.1827 | |||
| OIND | 203.3 | 339.9 | 75.6 | |||||
| RRMS | 240.5 | 526.3 | 52.4 | |||||
| SPMS | 428.6 | 813.9 | 100.7 | |||||
| PPMS | 356.6 | 534.2 | 126.0 | |||||
| PMS | 395.6 | 697.4 | 121.4 | |||||
| LT-α | HV+NIND | 1158.7 | 1399.7 | 548.4 | 0.0314 | RRMS vs. PMS | 0.023 | −389.0 |
| OIND | 1149.6 | 976.5 | 784.3 | |||||
| RRMS | 1091.2 | 1053.3 | 774.7 | |||||
| SPMS | 1417.5 | 1226.3 | 1064.6 | |||||
| PPMS | 1554.5 | 1265.1 | 1154.8 | |||||
| PMS | 1480.2 | 1239.3 | 1134.1 | |||||
| IL-10 | HV+NIND | 267.2 | 252.3 | 202.9 | 0.3021 | |||
| OIND | 170.2 | 215.4 | 72.8 | |||||
| RRMS | 102.5 | 127.8 | 51.5 | |||||
| SPMS | 191.6 | 249.3 | 95.1 | |||||
| PPMS | 130.5 | 159.5 | 68.9 | |||||
| PMS | 163.6 | 214.1 | 81.2 | |||||
| VEGF-A | HV+NIND | 2.2 | 3.3 | 1.1 | 0.7334 | |||
| OIND | 2.1 | 4.4 | 0.9 | |||||
| RRMS | 10.1 | 39.2 | 0.9 | |||||
| SPMS | 1.9 | 5.7 | 0.9 | |||||
| PPMS | 2.2 | 7.7 | 0.9 | |||||
| PMS | 2.1 | 6.7 | 0.9 | |||||
| VEGF-C | HV+NIND | 420.7 | 349.4 | 399.2 | 0.0293 | OIND vs. RRMS | 0.0422 | −121.2 |
| OIND | 377 | 345.0 | 346.1 | |||||
| RRMS | 498.2 | 274.6 | 401.8 | |||||
| SPMS | 394.2 | 214.1 | 373.3 | |||||
| PPMS | 369.0 | 203.2 | 408.1 | |||||
| PMS | 382.6 | 208.4 | 379.7 | |||||
| SPMS | 0.6 | 1.7 | 0.1 | |||||
| PPMS | 0.7 | 1.2 | 0.1 | |||||
| PMS | 0.6312 | 1.5 | 0.1 | |||||
| IL-6/IL-10 | HV+NIND | 2.3 | 3.5 | 0.6 | 0.9272 | |||
| OIND | 4.5 | 8.4 | 0.7 | |||||
| RRMS | 3.9 | 6.9 | 1.7 | |||||
| SPMS | 4.2 | 11.8 | 1.1 | |||||
| PPMS | 12.4 | 28.2 | 0.9 | |||||
| PMS | 7.9 | 21.25 | 0.9 | |||||
| TNF-α/IL-10 | HV+NIND | 11.9 | 16.2 | 2.7 | 0.0916 | |||
| OIND | 40.5 | 103.5 | 7.4 | |||||
| RRMS | 18.3 | 26.4 | 7.1 | |||||
| SPMS | 170.0 | 1017.5 | 9.9 | |||||
| PPMS | 54.6 | 83.2 | 13.4 | |||||
| PMS | 117.2 | 750.4 | 11.8 | |||||
| GM-CSF/IL-10 | HV+NIND | 1.0 | 1.5 | 0.4 | 0.2608 | |||
| OIND | 11.6 | 63.1 | 1.1 | |||||
| RRMS | 8.8 | 30.2 | 1.1 | |||||
| SPMS | 60.7 | 363.3 | 0.8 | |||||
| PPMS | 7.1 | 12.4 | 3.2 | |||||
| PMS | 36.2 | 267.9 | 1.7 | |||||
| LT-α/IL-10 | HV+NIND | 8.1 | 9.2 | 5.0 | 0.0212 | HV+NIND vs. PPMS | 0.0135 | −51.1 |
| OIND | 32.5 | 86.5 | 10.7 | HV+NIND vs. PMS | 0.0292 | −91.9 | ||
| RRMS | 28.9 | 50.9 | 9.8 | |||||
| SPMS | 134.5 | 784.7 | 9.1 | |||||
| PPMS | 59.2 | 114.9 | 15.7 | |||||
| PMS | 100.0 | 581.8 | 12.7 | |||||
| VEGF-A/IL-10 | HV+NIND | 0.02 | 0.02 | 0.01 | 0.6044 | |||
| OIND | 0.2 | 0.9 | 0.01 | |||||
| RRMS | 20.9 | 91.6 | 0.02 | |||||
| SPMS | 2.2 | 15.4 | 0.01 | |||||
| PPMS | 0.1 | 0.1 | 0.01 | |||||
| PMS | 1.2 | 11.35 | 0.01 | |||||
| VEGF-C/IL-10 | HV+NIND | 4.7 | 9.9 | 1.7 | 0.0085 | OIND vs. RRMS | 0.0210 | −183.7 |
| OIND | 10.1 | 25.7 | 2.7 | |||||
| RRMS | 193.8 | 650.9 | 7.5 | |||||
| SPMS | 38.4 | 190.9 | 3.3 | |||||
| PPMS | 18.7 | 44.5 | 2.9 | |||||
| PMS | 29.4 | 143.5 | 3.2 | |||||