Table 1.
Expression (log) of CD38 by gene expression profiling (GEP, RNA-sequencing) and flow cytometry.
| Population | GEP |
RNA-Seq |
Flow cytometry |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CD38 median | CD38 SD | CD38 min. | CD38 max. | FC MBC | LFC MBC | CD38 median | CD38 SD | CD38 min. | CD38 max. | FC MBC | LFC MBC | CD38 median | CD38 SD | CD38 min. | CD38 max. | |
| MBC | 3.56 | 1.43 | 2.70 | 6.44 | – | – | 2.50 | 0.54 | 1.83 | 2.92 | – | – | – | – | – | – |
| PPC | 11.47 | 0.35 | 11.40 | 12.24 | 241 | 229 | 8.70 | 0.25 | 8.43 | 8.90 | 74 | 61 | – | – | – | – |
| BMPC | 13.20 | 0.31 | 12.68 | 13.75 | 800 | 558 | 8.90 | 0.46 | 8.22 | 9.64 | 85 | 53 | 6.87 | 0.42 | 6.07 | 7.49 |
| AL | 12.88 | 0.82 | 7.43 | 14.57 | 641 | 15 | 8.62 | 0.61 | 6.30 | 10.12 | 70 | 14 | 5.99 | 0.60 | 4.09 | 7.49 |
| MGUS | 12.97 | 0.56 | 11.40 | 14.52 | 681 | 229 | 8.65 | 0.68 | 5.80 | 10.04 | 71 | 10 | 6.23 | 0.60 | 3.83 | 7.33 |
| AMM | 12.63 | 0.80 | 10.10 | 14.78 | 538 | 93 | 8.41 | 0.79 | 5.48 | 9.52 | 60 | 8 | 5.83 | 0.51 | 4.38 | 7.15 |
| MM | 12.48 | 1.04 | 7.05 | 15.42 | 484 | 11 | 8.47 | 0.90 | 4.05 | 10.69 | 63 | 3 | 5.88 | 0.60 | 4.28 | 7.34 |
| MMR | 12.38 | 0.81 | 10.27 | 13.75 | 252 | 105 | – | – | – | – | – | – | 5.68 | 0.67 | 3.89 | 7.44 |
| HMCL | 8.64 | 3.01 | 2.84 | 12.53 | 34 | 0.98 | 5.65 | 2.42 | 0.31 | 9.68 | 9 | 1 | 5.04 | 0.64 | 3.99 | 6.52 |
MBC, memory B-cells; PPC, polycloncal plasmablastic cells; BMPC, (normal) bone marrow plasma cells; AL, AL-amyloidosis; MGUS, monoclonal gammopathy of unknown significance; (A)MM, (asymptomatic) multiple myeloma; MMR, relapsed multiple myeloma; HMCL, human myeloma cell line; SD, standard deviation; Min, minimum expression; Max, maximum expression; FC MBC, fold change of CD38 expression of the respective population vs. MBC; LFC MBC, lowest fold change of CD38 expression of the respective population vs. MBC.