Table 1.
Expression of sex steroid receptors in human and murine innate immune cells.
| Cell type | ERα | ERβ | Other ERs | PRs | AR | ERα | ERβ | PRs | AR |
|---|---|---|---|---|---|---|---|---|---|
| Human | Murine | ||||||||
| Type II innate lymphoid cells | Yes (27)/No (28) | Yes (27)/No (28) | −/+ | Yes (28–30) | |||||
| Natural killer cells (NK) | Yes (31, 32) | Yes (31, 32) | ERα46 (31) | Yes (33) | − | Yes (34) | Yes (34) | − | −/+ |
| Gamma delta T cells (γδ T) | Yes (35) | −/+ or + | −/+ | − | + or − | ||||
| Natural killer T cells | − | −/+ | − | − | Yes (36) | −/+ | − | − or −/+ | |
| Neutrophils | Yes (37) | Yes (37) | GPER (38) | No (39) | Yes (40) | −/+ | − | − | Yes (41) |
| Eosinophils | −/+ | −/+ | GPER (42) | No (39) | No (40) | −/+ | − | − | − |
| Plasmacytoid dendritic cells (pDC) | Yes (32) | Yes (32) | − | − | Yes (43) | − | −/+ | − | |
| Monocytes | Yes (23, 32, 44, 45) | Yes (23, 32, 44, 45) | ERα46 (23) | − | − | + | −/+ | − | − |
| Dendritic cell (tissue-resident, monocyte-derived, BM-derived) | Yes (32, 45) | Yes (32, 45) | − | − | Yes (46, 47) | Yes (46, 47)/No (48) | −/+ | − | |
| Macrophage (alveolar, BM-derived, peritoneal) | Yes (23, 49, 50) | Yes (23, 49, 51) | ERα46 (23) | Yes (49) | Yes (40, 52) | Yes (48, 53) | Yes (50)/No (48, 53) | Yes (54) | Yes (55) |
| Hematopoietic stem cell | Yes (26) | Yes (26) | − | Yes (26) | Yes (56) | No (56) | No (56) | No (56) | |
The presence of sex steroid receptors in each cell type (located in any tissue and regardless of activation state) is indicated by “Yes” or “No” and the literature reference. Some cell types differ in receptor expression in different tissues, and this is indicated by “Yes/No.” If a literature report was not found, we consulted the Immunological Genome Project, and the presence or absence of receptor RNA is indicated in blue if available.
−, <50 counts; −/+, 50–100 counts; +, 100–300 counts; + or − represents positive or negative value depending upon the tissue location.