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. 2018 Jul 20;9:726. doi: 10.3389/fphar.2018.00726

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Copyright © 2018 Lee, Kim, Choi, Choi, Jeong, Park, Choi and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of the progression of rheumatoid arthritis (RA) using a murine collagen-induced arthritis (CIA) model. Mice with CIA were orally administered 4-HMC or Dexa from day 28 after the primary immunization. RA severity was monitored based on the clinical arthritis score, the incidence of arthritic paws, and paw thickness, which was measured using a dial thickness gauge. The data are presented as the mean ± SD of five determinations. ^∗∗∗p < 0.001; ^∗∗p < 0.01; ^∗p < 0.05, significantly different from untreated CIA mice. 4-HMC, 4-(hydroxymethyl)catechol; Dexa, dexamethasone.