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. 2018 Jul 12;5(3):e10200. doi: 10.2196/10200

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©Eyal Karin, Blake F Dear, Gillian Z Heller, Milena Gandy, Nickolai Titov. Originally published in JMIR Mental Health (http://mental.jmir.org), 12.07.2018.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Mental Health, is properly cited. The complete bibliographic information, a link to the original publication on http://mental.jmir.org/, as well as this copyright and license information must be included.

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Measurement of mean treatment-related PHQ-9 symptom change per initial pretreatment symptom severity band; whiskers represent 95% CI s. Symptom change observed under control conditions indicated by a solid trend line.