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. 2018 Jul 26;56(8):e00471-18. doi: 10.1128/JCM.00471-18

TABLE 2.

Impact of caspofungin or fluconazole on the sensitivity and performance of BacT/Alerta FA blood culture bottles and the T2Candida assay in the detection of Candida spp. at low and high inoculum levelsa

Candida species Instrument Inoculum of ∼1–5 cells/ml
Inoculum of ∼10–50 cells/ml
No. of cells/ml ND (%) CAS (%) FLU (%) No. of cells/ml ND (%) CAS (%) FLU (%)
All species BacT/Alert 1.7–5.7 97.5 97.5 85 17–57 100 100 92.5
T2CA 95 95 95 100 100 100
C. albicans BacT/Alert 1.7–4.7 100 100 50 17–47 100 100 87.5
T2CA 100 100 100 100 100 100
C. tropicalis BacT/Alert 2.7–4.2 100 87.5 87.5 27–42 100 100 100
T2CA 100 100 100 100 100 100
C. glabrata BacT/Alert 2–5.7 100 100 100 20–57 100 100 100
T2CA 87.5 87.5 100 100 100 100
C. krusei BacT/Alert 2.4–4.3 100 100 87.5 24–43 100 100 75
T2CA 87.5 87.5 87.5 100 100 100
C. parapsilosis BacT/Alert 3.2–4.9 87.5 100 100 32–49 100 100 100
T2CA 100 100 87.5 100 100 100
a

Low inoculum, 1 to 5 cells/ml; high inoculum, 10 to 50 cells/ml; ND, no drug; CAS, caspofungin; FLU, fluconazole; T2CA, T2Candida assay.