TABLE 2.
Impact of caspofungin or fluconazole on the sensitivity and performance of BacT/Alerta FA blood culture bottles and the T2Candida assay in the detection of Candida spp. at low and high inoculum levelsa
Candida species | Instrument | Inoculum of ∼1–5 cells/ml |
Inoculum of ∼10–50 cells/ml |
||||||
---|---|---|---|---|---|---|---|---|---|
No. of cells/ml | ND (%) | CAS (%) | FLU (%) | No. of cells/ml | ND (%) | CAS (%) | FLU (%) | ||
All species | BacT/Alert | 1.7–5.7 | 97.5 | 97.5 | 85 | 17–57 | 100 | 100 | 92.5 |
T2CA | 95 | 95 | 95 | 100 | 100 | 100 | |||
C. albicans | BacT/Alert | 1.7–4.7 | 100 | 100 | 50 | 17–47 | 100 | 100 | 87.5 |
T2CA | 100 | 100 | 100 | 100 | 100 | 100 | |||
C. tropicalis | BacT/Alert | 2.7–4.2 | 100 | 87.5 | 87.5 | 27–42 | 100 | 100 | 100 |
T2CA | 100 | 100 | 100 | 100 | 100 | 100 | |||
C. glabrata | BacT/Alert | 2–5.7 | 100 | 100 | 100 | 20–57 | 100 | 100 | 100 |
T2CA | 87.5 | 87.5 | 100 | 100 | 100 | 100 | |||
C. krusei | BacT/Alert | 2.4–4.3 | 100 | 100 | 87.5 | 24–43 | 100 | 100 | 75 |
T2CA | 87.5 | 87.5 | 87.5 | 100 | 100 | 100 | |||
C. parapsilosis | BacT/Alert | 3.2–4.9 | 87.5 | 100 | 100 | 32–49 | 100 | 100 | 100 |
T2CA | 100 | 100 | 87.5 | 100 | 100 | 100 |
Low inoculum, 1 to 5 cells/ml; high inoculum, 10 to 50 cells/ml; ND, no drug; CAS, caspofungin; FLU, fluconazole; T2CA, T2Candida assay.