Table 3.
Immunoreactivity of HNF-1B in PDAC and non-pancreatic carcinomas
| Cancer type | Total No. | HNF-1B + | Stain pattern | Fisher’s exact p-value |
|---|---|---|---|---|
| Pancreatic primary | 127 | 107 (84.3%) | C, N, M | ref |
| Cholangiocarcinoma | 15 | 13 (86.7%) | C, N, M | .81 |
| Ampullary | 18 | 13 (72%) | C, N, M | .21 |
| Gallbladder | 14 | 13 (92.9%) | C, N, M | .69 |
| Colorectal | 39 | 0 | – | <.001 |
| Hepatocellular | 20 | 0 | – | <.001 |
| Esophagus | 11 | 3 (27.3%) | C, N | <.001 |
| Stomach | 14 | 9 (64.3%) | C, N | .13 |
| Lung adenocarcinoma | 24 | 6 (25%) | C, N | <.001 |
| Lung Squamous cell | 10 | 0 | – | <.001 |
| Breast | 20 | 0 | – | <.001 |
| Bladder | 18 | 7 (38.9%) | C, N | <.001 |
| Prostate | 15 | 4 (26.7%) | C, N | <.001 |
| Kidney | 21 | 16 (76.2%) | N | .35 |
| Ovary | 18 | 14 (77.8%) | N, C | .50 |
| Uterus | 21 | 10 (47.6%) | N, C | <.001 |
| Metastatic PDAC | 17 | 16 (94.1%) | N, C | |
| Total No. | 422 |
Abbreviations: PDAC, pancreatic ductal adenocarcinoma;
SCC squamous cell carcinoma, C cytoplasmic, N nuclear, M membranous