Table 2.
Basic information of candidate SNPs in Han subjects
| SNP_ID | Gene | Alleles A/B | Case (N) | Control (N) | OR (95% CI) | P | P1 | P2 | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AA | AB | BB | AA | AB | BB | |||||||
| rs7518602 | PIK3CD | C/T | 4 | 16 | 50 | 0 | 6 | 23 | 3.899 (1.515–10.290) | 0.961 | 0.261 | 0.425 |
| rs7516138 | PIK3CD | G/A | 4 | 19 | 47 | 0 | 11 | 18 | 4.150 (1.615–10.989) | 0.993 | 0.959 | 0.800 |
| rs7516214 | PIK3CD | G/A | 4 | 19 | 46 | 0 | 11 | 18 | 4.070 (1.582–10.786) | 0.993 | 0.924 | 0.829 |
| rs11805716 | PIK3CD | T/C | 13 | 17 | 32 | 3 | 9 | 14 | 3.610 (1.335–10.014) | 0.961 | 0.516 | 0.488 |
| rs11806839 | PIK3CD | G/C | 7 | 11 | 12 | 2 | 6 | 6 | 2.800 (0.640–12.570) | 0.993 | 0.627 | 0.616 |
| rs79190623 | PIK3CD | C/T | 63 | 7 | 0 | 23 | 6 | 0 | 3.952 (1.533–10.448) | 0.766 | 0.160 | 0.245 |
| rs72633866 | PIK3CD | G/A | 64 | 4 | 0 | 22 | 6 | 0 | 5.107 (1.892–14.498) | 0.236 | 0.033 | 0.014 |
| rs2230735 | PIK3CD | A/G | 63 | 7 | 0 | 23 | 6 | 0 | 3.952 (1.533–10.448) | 0.766 | 0.160 | 0.245 |
| rs182137610 | PIK3CD | A/C | 63 | 7 | 0 | 24 | 5 | 0 | 3.961 (1.540–10.444) | 0.961 | 0.321 | 0.510 |
| rs188191807 | PIK3CD | G/A | 57 | 3 | 0 | 23 | 3 | 0 | 4.280 (1.564–12.125) | 0.961 | 0.287 | 0.486 |
| rs28730671 | PIK3CD | C/T | 65 | 5 | 0 | 23 | 6 | 0 | 3.808 (1.463–10.129) | 0.509 | 0.061 | 0.129 |
| rs111888887 | PIK3CD | T/C | 65 | 5 | 0 | 24 | 5 | 0 | 3.816 (1.471–10.117) | 0.821 | 0.141 | 0.312 |
| rs9430220 | PIK3CD | T/C | 37 | 28 | 4 | 9 | 18 | 2 | 5.044 (1.871–14.464) | 0.245 | 0.081 | 0.029 |
| rs28730674 | PIK3CD | A/G | 65 | 5 | 0 | 23 | 6 | 0 | 3.808 (1.463–10.129) | 0.509 | 0.061 | 0.129 |
| rs371870925 | PIK3CD | T/C | 65 | 3 | 0 | 24 | 5 | 0 | 4.016 (1.520–10.884) | 0.509 | 0.050 | 0.112 |
| rs199962152 | PIK3CD | A/G | 63 | 2 | 0 | 22 | 5 | 0 | 3.065 (1.118–8.502) | 0.245 | 0.024 | 0.034 |
| rs77571929 | PIK3CD | T/C | 64 | 5 | 0 | 23 | 6 | 0 | 3.737 (1.439–9.970) | 0.509 | 0.065 | 0.132 |
| rs117226273 | PIK3CD | G/T | 65 | 5 | 0 | 23 | 6 | 0 | 3.808 (1.439–10.129) | 0.509 | 0.061 | 0.129 |
| rs28730676 | PIK3CD | T/C | 65 | 5 | 0 | 23 | 6 | 0 | 3.808 (1.436–10.129) | 0.509 | 0.061 | 0.129 |
| rs10864435 | PIK3CD | C/T | 63 | 7 | 0 | 20 | 9 | 0 | 6.247 (2.235–18.787) | 0.051 | 0.013 | 0.002 |
| rs28730677 | PIK3CD | G/A | 65 | 5 | 0 | 24 | 5 | 0 | 3.816 (1.471–10.117) | 0.821 | 0.141 | 0.312 |
| rs10178458 | COL4A3 | T/C | 0 | 9 | 61 | 0 | 4 | 25 | 4.116 (1.069–10.826) | 0.993 | 0.900 | 0.803 |
| rs6436669 | COL4A3 | A/G | 0 | 9 | 61 | 0 | 4 | 25 | 4.116 (1.069–10.826) | 0.993 | 0.900 | 0.803 |
| rs80109666 | COL4A3 | G/A | 49 | 19 | 2 | 22 | 7 | 0 | 3.984 (1.545–10.552) | 0.993 | 0.433 | 0.707 |
| rs55703767 | COL4A3 | G/T | 53 | 15 | 2 | 21 | 7 | 1 | 4.088 (1.600–10.732) | 0.993 | 0.732 | 0.762 |
| rs10205042 | COL4A3 | C/T | 2 | 15 | 53 | 1 | 7 | 21 | 4.073 (1.592–10.704) | 0.993 | 0.732 | 0.869 |
| rs34505188 | COL4A3 | G/A | 46 | 19 | 5 | 18 | 11 | 0 | 4.214 (1.637–11.199) | 0.993 | 0.787 | 0.587 |
| rs11677877 | COL4A3 | A/G | 46 | 19 | 5 | 17 | 12 | 0 | 4.187 (1.625–11.138) | 0.993 | 0.997 | 0.725 |
| rs34019152 | COL4A3 | G/A | 46 | 19 | 5 | 18 | 11 | 0 | 4.214 (1.637–11.199) | 0.993 | 0.787 | 0.587 |
| rs28381984 | COL4A3 | C/T | 27 | 32 | 11 | 9 | 16 | 4 | 4.160 (1.623–10.984) | 0.993 | 0.711 | 0.599 |
SNP single-nucleotide polymorphism, OR odds ratio, 95% CI 95% confidence interval, P value FDR-calculated P value, P1 P value calculated by unconditional logistic regression analysis, P2 P value adjusted for age