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. 2018 Jul 27;19:261. doi: 10.1186/s12891-018-2203-7

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Overview and magnification (2.5×) of the fracture region stained with van Kossa/Safranin Orange (mineralized tissue: black; cartilage and fibrous tissue: red): In the non-infected control group the callus is mineralized (*). No fracture healing is visible in the infected control group (+S. aureus) with fibrous tissue and cartilage (**) filling the gap. Bone healing of the fracture is increased in both rhBMP groups with less fibrous tissue and less cartilage filling. I) control group, II) infected control group (+S. aureus), III) rhBMP-7 group (rhBMP-7 + S. aureus) and IV) rhBMP-2 group (rhBMP-2 + S. aureus); mineralized tissue: *; fibrous tissue and cartilage: **; muscles: mu