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The Cre-Lox excision system. The DNA sequences for the OSKM factors are flanked by LoxP sites and delivered virally to the target cells of interest. The Cre-recombinase is delivered in parallel in a similar manner. When expressed, the Cre-recombinase excises the sequences by recombination of the two flanking LoxP sites. This excision will nevertheless leave a residual LoxP site at the site of the original insertion
