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. 2018 Jul 27;18:106. doi: 10.1186/s12935-018-0600-5

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Effects of coilin knockdown in leukemia cells following DNR (0.03 μg/ml) treatments. a Flow cytometry analyses for apoptosis in Reh cells infected with a lenti-virus expressing a scrambled control or a shRNA targeting coilin. b Quantification on apoptosis (*p = 0.019, n = 3) from cells subjected to the same treatments as in a. c The cell survival measures in sh-Coilin infected Reh cells without or with DNR treatments (*p = 0.002, ^#p = 0.014, n = 3). d Western blot of p27 and γH2AX from leukemia cells treated with DNR (0.03 μg/ml). Quantification (n = 3) of coilin, p27 and γH2AX proteins relative to GAPDH levels. The expression of coilin and p27 were decreased (*p = 0.009, p = 0.044); whereas γH2AX was increased (*p = 0.001)