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. 2018 Jul 27;18:225. doi: 10.1186/s12906-018-2293-7

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Pharmacological interaction isobolograms among major terpenes of the Citral and Carvone chemotype L. alba essential oils: a limonene with caryophyllene oxide; b limonene with carvone; c limonene with citral; and d limonene with Benznidazole (BNZ). The interaction tests were performed on Epimastigotes, Trypomastigotes and Amastigotes of T. cruzi and Vero cells. Dotted lines correspond to an additive effect; points below, on, and above line indicate a synergistic, additive, and antagonistic effect, respectively