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. 2018 Jul 27;37:172. doi: 10.1186/s13046-018-0838-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — circRNA expression profiles in HCC. a The cluster heat map showed the top 20 upregulated and downregulated circRNAs in HCC tissues. Red color indicates high expression level and green color indicates low expression level. b The scatter plot revealed the variation in circRNA expression between HCC tissues and matched para-carcinoma normal tissues. The values of x and y axes were the normalized signal values of the samples (log2 scaled). c-g qRT-PCR was performed to verify the expression of the top five upregulated circRNAs in HCC cell lines. All the data are shown as the mean ± S.D