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. 2018 Jul 27;19:131. doi: 10.1186/s12881-018-0649-y

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Patients’ brain magnetic resonance images (MRIs). Axial T2-weighted MRI (a) of Case II-1 taken at 2 weeks of age shows a simplified gyral pattern with too few and shallow sulci and normal cortical thickness. Follow-up axial T2-weighted MR image (b) acquired at 4 months of age shows a progression of diffuse brain atrophy with subarachnoid space widening. Axial T2-weighted MRI (c) of Case II-2 obtained at 3 weeks of age shows a similar pattern of simplified sulcation as the sibling. Note extensive fluid collection in the scalp (arrows)