Figure 5.

DCs loaded with the lysate of tumor cells infected with the NDV enhanced the secretion of IFN-γ from CD4⁺ and CD8⁺ T cells. (A) A representative flow cytometry plot demonstrating the percentage of IFN-γ-positive cells among CD4⁺ and CD8⁺ T cells co-cultured with the three types of DCs. The percentage of IFN-γ-positive cells among (B) CD4⁺ and (C) CD8⁺ T cells co-cultured with the three types of DCs induced from peripheral blood monocytes of 12 patients with lung cancer. (D) Soluble IFN-γ release in the supernatant of T cells co-cultured with the three types of DC. All error bars represent the mean ± standard deviation. *P<0.05; **P<0.01; n.s., not significant; IFN-γ, interferon-γ; CD4, cluster of differentiation 4; NDV-TCL-DCs, Newcastle Disease Virus-tumor cell lysate-dendritic cells; T, T cell.