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. 2018 May 21;16(1):1205–1211. doi: 10.3892/ol.2018.8750

Figure 6.

Figure 6.

CSF-1R overexpression enhances the activity of PI3K/Akt in 6–10B cells. (A) CSF-1R overexpression activates the PI3K/Akt signaling pathway in 6–10B cells, confirmed by an enhanced signal for p-Akt in western blot analysis. (B) The expression of cyclin D1 was increased compared with the control group. (C) Expression of Bcl-2 was increased, while the expression of Bax was reduced in the transfection group, compared with the control group. (D) The relative expression levels in the transfection group and the control group were assessed. GADPH was used as the loading control for the western blot analyses. **P<0.01 compared with the control group. CSF-1R, colony-stimulating factor 1 receptor; PI3K, phosphoinositide 3-kinase; Akt, protein kinase B; p-Akt, phosphorylated Akt; Bcl-2, B-cell lymphoma 2.