Scheme 1. Synthesis of ABC ProTides. Reagent and conditions: Step 1(a) 1-docosanol, HATU, imidazole, Et₃N, DMF/CHCl₃, 45 °C, 48 h; Step 1(b) Pd/C, Et₃SiH, MeOH/CHCl₃ (1 : 1 v/v), rt, 16 h. Step 2(a) phenyl dichlorophosphate, Et₃N, CH₂Cl₂, –78 °C–rt, 16 h. Step 3(a) ABC, tert-BuMgCl, THF, –78 °C–rt, 48–90 h.