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. 2018 Jul 3;24:4592–4601. doi: 10.12659/MSM.908652

Figure 5.

Figure 5

In vivo experiments demonstrated the inhibitory effect of LINC00312 on proliferation and invasion of TC cells. (A, B) In the subcutaneous model of TC, overexpression of LINC00312 inhibited the growth of TC, but the growth of TC in the si-LINC00312 group was significantly increased; (C, D) The expression of MMP9 in tumor tissues was detected by immunohistochemistry, showing that overexpression of LINC00312 reduced the percentage of MMP9 positive cells, and low expression increased the percentage of MMP9 positive cells; (E, F) The results of Western blotting showed that overexpression of LINC00312 reduced the expression of PI3K and p-Akt. * Compared with the blank group, P<0.05; # compared with the si-control group, P<0.05. Results presented as the mean ±SD with 3 independent experiments.