Figure 7.

SCF^PROM-1 loss of function in combination with gld-2 null results in synthetic overproliferation. Images of dissected germlines from young-adult gld-2 (top) and gld-2 prom-1 (bottom) mutant hermaphrodites, labeled with EdU for 4 hr (green), and costained for CYE-1 (yellow) and DAPI (cyan). ☆ indicates distal gonadal end. Dashed yellow (top) or red (bottom) lines indicate position of overt meiotic entry. Solid yellow lines indicate continuous EdU zone. Solid red lines indicate continuous CYE-1 accumulation. White arrow indicates proximal proliferation; pink arrow indicates stray EdU+ cells proximal to progenitor zone. Dotted white lines indicates proximal end of the germlines.