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Locomotor function of LRRK2 G2019S flies depends on genetic background. Negative geotaxis of Ddc-GAL4; UAS-LRRK2-G2019S flies in 148 DGRP backgrounds at 2 and 6 weeks of age. DGRP background has a strong effect on locomotor performance at both ages (2 weeks, P < 1.08 × 10−66; 6 weeks, P < 4.04 × 10−44).
