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. 2018 Jun 15;209(4):1345–1356. doi: 10.1534/genetics.118.301119

Figure 2.

Figure 2

Effect of candidate modifier gene KD on LRRK2 G2019S locomotor dysfunction. Top association candidates were tested at 2 weeks (A) and 6 weeks (B) of age. Neuron projection candidates were tested at 2 weeks (C) and 6 weeks (D) of age. In each case, there was a significant effect of genotype on geotaxis (individual ANOVAs, P < 0.0006). In 6-week-old flies, Bonferroni post-tests revealed a significant effect of G2019S LRRK2 expression and an enhancement or suppression effect of RNAi for some candidate genes on the performance of G2019S LRRK2-expressing flies (ns not significant, * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001). Ctrl is +/+; UAS-LRRK2-G2019S/+ and LRRK2 G2019S is Ddc-GAL4/+; UAS-LRRK2-G2019S/+.