Table 3.

Pleiotropies Found in Each Category.

Hallmarks of Aging	Genes	SNPs	n Pleios	Pleios/SNP	P value	SNPs/Genes
Cellular senescence	51	44	29	0.65	<2.2e-16*	0.86
Telomere attrition	117	43	26	0.60	1.94e-15*	0.36
Mitochondrial dysfunction	228	80	27	0.33	1.68e-08*	0.35
Genomic instability	483	96	27	0.28	1.09e-06*	0.19
Altered intracellular communication	624	354	65	0.18	4.68e-06*	0.56
Epigenetic alterations	528	172	34	0.19	0.00018	0.32
StemCell exhaustion	105	75	13	0.17	0.0449	0.71
Loss of proteostasis	811	210	26	0.12	0.2	0.25
Deregulated nutrient sensing	185	58	8	0.13	0.25	0.31
Wound healing	561	181	47	0.26	2.66e-09*	0.32
Blood coagulation	324	110	27	0.25	2.33e-05*	0.34

Note.—*Asterisks represent significant categories after FDR correction.