Fig. 7:

transcription factor binding motif enrichment in regions with exposure-induced 5hmC and/or 5mC changes. Enrichment of transcription factor binding motifs in genomic regions with 5hmC and/or 5mC changes following exposures. Enrichment was calculated using the HOMER software package and the Cis-BP motif library (see Methods). The top 30 significantly enriched binding motifs are grouped by their corresponding transcription factors. The Y-axis indicates the significance (–log P-value) of the enrichment of the given motif. The X-axis indicates the corresponding TF, in decreasing order of significance. Box size indicates the fold-enrichment over background (see key below). (A) all locations with exposure-induced 5hmC changes; (B) all locations with exposure-induced 5mC changes; (C) 5hmC gain, 5mC no change; (D) 5mC loss, 5hmC gain; (E) 5mC gain, 5hmC no change; (F) 5mC loss, 5hmC no change; (G) 5mC gain, 5hmC loss; (H) 5hmC loss, no changes in 5mC.