Table 1.
Histone acetyltransferase (HAT) subfamilies and enzymes in humans
| Subfamily | Enzyme examples | Alternative nomenclature | Histone residues acetylated |
|---|---|---|---|
| GNAT superfamily | GCN5 | KAT2 | H3 (H4, H2B) |
| PCAF | KAT2B | H3, H4 | |
| HAT1 | KAT1 | H2AK5, H3, H4 | |
| ELP3 | KAT9 | H3 | |
| MYST | Tip60 | KAT5 | H2A, H3, H4 |
| MOZ | KAT6A | H3, H4 | |
| MORF | KAT6B | H2A, H3, H4 | |
| HBO1 | KAT7 | H3, H4 | |
| MYST1 | KAT8 | H4 | |
| p300/CBP | p300 | KAT3B | H2A, H2B, H3, H4 |
| CBP | KAT3A | H2A, H2B, H3, H4 | |
| Transcription factors | TAFII250 | H3, H4 | |
| TFIIIC90 | KAT12 | H2A, H3, H4 | |
| CLOCK | KAT13D | H3, H4 | |
| Nuclear receptor cofactors | SRC1 | KAT13A | H3, H4 |
| ACTR | KAT13B | H3, H4 | |
| TIF2 | KAT13C | H3, H4 |
Adapted from Refs. [52, 166, 167]
GNAT Gcn5-related N-acetyltransferases, KAT K-acetyltransferase, PCAF p300/CBP-associated factor, HAT1 histone acetyltransferase 1, ELP3 elongator protein complex 3, MOZ monocytic leukemia zinc finger protein, MORF monocyte leukemia zinc finger protein-related factor, HBO1 histone acetyltransferase binding to ORC-1, CBP CREB-binding protein, CLOCK clock circadian regulator, SRC1 steroid receptor coactivator-1, TIF2 transcriptional mediators/intermediary factor 2