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. 2018 Jun 8;92(8):2487–2500. doi: 10.1007/s00204-018-2239-3

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Methylation of cg16447589 is associated with IGFBP3 concentrations in plasma and prenatal arsenic exposure. a Methylation of cg16447589 is negatively associated with IGFBP3 concentrations in plasma in boys and positively associated in girls. b Prenatal exposure to As, expressed as natural log-transformed maternal arsenic in urine in gestational week 8 [ln(As in urine GW 8)], is negatively associated with methylation of cg16447589 in boys and positively associated in girls. Lines indicate the regression line, and the shadows represent the 95% confidence interval