Table 2.

MMP inhibition potencies and clogD (logD) values of lead structures and target novel hydroxamic acids

	IC50 [nM]a				log D values
Compound	R	X	MMP-2	MMP-9	clogDb	logD (exp.)	Ref.
(R)-CGS 27023A	CH3	N	20c	8c	1.49		(Mac Pherson et al., 1997)
(R)-CGS 25966	CH3	CH	11c	27c	2.72		(Scozzafava and Supuran, 2000)
(R)-FEtO- CGS 25966	CH2CH2F	CH	4 ± 3	50 ± 27	2.92	2.02 ± 0.03	(Wagner et al., 2011)
(R)-2	CH3	N	9.3 ± 2.0	8.3 ± 0.1	0.81		(Behrends et al., 2015)
(S)-2	CH3	N	7.2 ± 0.1	4.9 ± 0.4	0.81		(Behrends et al., 2015)
(R)-9a	CH2CH2F	CH	10.4 ± 5.9	0.5 ± 0.3	2.23
(S)-9a	CH2CH2F	CH	0.3 ± 0.03	0.1 ± 0.01	2.23	1.16 ± 0.2d

^aStandard deviations based on three independent experiments are given for IC₅₀ values in nM range

^bclogD values were calculated by ChemAxon LogD predictor, (logD = logP at physiological pH 7.4)

^cK_i values, where SDs are not denoted

^dlogD value was determined for compound (S)-[¹⁸F]9a