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. 2018 Jun 28;92(8):2587–2606. doi: 10.1007/s00204-018-2250-8

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — LUHMES 3D model for acute, recovery, and resilience experiments. a LUHMES differentiated in 3D on a gyratory shaker showing b RFP-expressing cells (red) and TH (green), nuclei (blue). c LUHMES 3D treatment and wash-out scheme for recovery and resilience (second hit) experiments and endpoints. d Medium rotenone quantification prior to treatment, day 8 and day 15. From left to right, bars correspond to negative control (medium without rotenone), positive control (medium with rotenone prior to treatment), 24 h treatment control (medium with rotenone in plates), 24 h treatment (medium with rotenone in plates with aggregates), 7 day wash-out control (medium with rotenone in plates on day 15 after wash-out), and 7 day wash-out treated cells (medium with rotenone in plates on day 15 after wash-out with aggregates). e Amount of rotenone bound to plastic and cells after 24 h exposure (day 8). (Color figure online)