Fig. 7.

Rotenone-induced transcriptome changes on day 8 (24 h) vs. day 15 (wash-out). a Volcano plots show the global changes in transcriptome for day 8 and day 15. b Venn diagram shows the number of up- and downregulated genes on day 8 [D8 (24 h)] and on day 15 [D15 (wash-out)] (FC > 1.5, p < 0.01). Ten genes were in intersection between two conditions, which are listed in c. For this diagram, the p values were not adjusted for multiple testing. ACTA1actin alfa 1, skeletal muscles, PPP1R27 protein phosphatase 1, regulatory subunit 27, GDF15 growth differentiation factor 15, CCK cholecystokinin, CD200 OX-2 membrane glycoprotein, LCP1 plastin 2 (lymphocyte cytosolic protein 1), ZFHX4 AS1-ZFHX4 (Zinc-Finger Homeobox 4) antisense RNA 1, FRMPD2 FERM and PDZ domain containing 2, FRMPD2 FERM and PDZ domain containing 2, GRXCR1 glutaredoxin and cysteine-rich domain containing 1