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. Author manuscript; available in PMC: 2018 Jul 27.
Published in final edited form as: Cell Rep. 2018 Jul 3;24(1):66–78.e8. doi: 10.1016/j.celrep.2018.06.023

Figure 5. Wnt Signaling Acts Permissively Upstream of FGF Signaling for Segmental Determination.

Figure 5.

(A) Levels of ppERK (top) and nuclear ß-catenin (bottom) following 50 min heat shock perturbation of FGF signaling (green) in comparison with control data for the same stage (black).

(B) Levels of ppERK following 50 min heat shock perturbation of Wnt signaling (blue) in comparison with control data for the same stages (black) over a time course of 2 hr.

(C) Change of somite sizes following the heat shock inhibition of Wnt signaling from 12 to 14 somite stages.

(D) Wnt signaling acts upstream of FGF in segment sizes as a permissive cue in the posterior PSM.

(E) SFC of FGF signaling shifts 2 hr after heat shock posteriorly due to the inhibition of Wnt signaling.

(F) Shift of SFC readout of FGF signaling (δ) matches with the increase of somite size due to Wnt inhibition (C).

Error bars indicate SEM. Posterior is left. See also Figures S1, S4, and S5.

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