Table 3. Independently associated variants identified using sequential forward selection with PCBS method.

Sequential conditional analyses for the 9 loci were conducted, where we iteratively performed conditional analysis, conditioning on the top variants from earlier rounds. Top association signals at each iteration are shown. The sequential conditional analysis stops when the top association signal is no longer significant under the genome-wide significance threshold α = 5 × 10⁻⁸.

POS	RS	REF	ALT	AF	PVALUE	BETA	SE	N		ANNO	GENE
Locus rs2072659 Marginal association analysis
1:154548521	rs2072659	C	G	0.1	1.9 × 10−8	-0.041	7.3 × 10−3	134862		Utr3	CHRNB2
Locus rs550432263 Marginal association analysis
5:1385253	rs550432263	G	A	2.8 × 10−6	3.6 × 10−8	71	13	34858		Intergenic	SLC6A3
Locus rs9366836 Marginal association analysis
6:34009601	rs9366836	A	G	0.17	3.3 × 10−8	0.028	5.2 × 10−3	134862		Intron	GRM4
Locus rs215600 Marginal association analysis
7:32333642	rs215600	G	A	0.64	4.8 × 10−11	-0.027	4.0 × 10−3	134862		Intron	PDE1C
Locus rs58379124 Marginal association analysis
8:42579203	rs58379124	T	C	0.77	4.4 × 10−14	0.035	4.6 × 10−3	134862		Intron	CHRNB3
Locus rs1217106 Marginal association analysis
8:64567670	rs1217106	A	G	0.78	2.2 × 10−9	-0.028	4.4 × 10−3	134862		Intergenic	YTHDF3
Locus rs56116178 Marginal association analysis
9:136460224	rs56116178	A	G	0.11	2.5 × 10−9	0.038	6.3 × 10−3	134862		Intergenic	FAM163B-DBH
Locus rs11852372 Marginal association analysis
15:78801394	rs11852372	A	C	0.34	7.7 × 10−115	0.096	4.2 × 10−3	128249		Intron	AGPHD1
Conditional on rs11852372
15:78896129	rs1317286	A	G	0.34	1.7 × 10−22	0.027	2.8 × 10−3	128249		Intron	CHRNA3
Conditional on rs11852372 and rs1317286
15:78814389	rs7181245	C	T	0.21	2.5 × 10−13	-0.032	4.4 × 10−3	128249		Intron	AGPHD1
Conditional on rs11852372, rs1317286 and rs7181245
15:78911181	rs8040868	T	C	0.40	2.2 × 10−11	0.020	2.9 × 10−3	128249	Synonymous		CHRNA3
Conditional on rs11852372, rs1317286, rs7181245 and rs8040868
15:78739763	rs2089162	A	G	0.33	3.5 × 10−8	0.011	2.0 × 10−3	128249		Intron	IREB2
Locus rs56113850 Marginal association analysis
19:41353107	rs56113850	T	C	0.58	6.6 × 10−67	0.070	4.0 × 10−3	128249		Intron	CYP2A6
Conditional on rs56113850
19:41371480	rs117824460	A	G	0.029	6.2 × 10−23	-0.13	0.013	128249		Intergenic	CYP2A6
Conditional on rs56113850 and rs117824460
19:41406448	rs117540499	G	A	0.023	2.4 × 10−17	-0.11	0.013	128249		Intergenic	CYP2A6
Conditional on rs56113850, rs117824460 and rs117540499
19:41345395	rs7246742	T	G	0.13	1.9 × 10−8	-0.033	5.9 × 10−3	128249		Intergenic	CYP2A6