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. 2018 Jun 25;128(8):3319–3332. doi: 10.1172/JCI98194

Figure 3. Sec24c deficiency leads to widespread apoptotic cell death in embryonic brains.

Figure 3

(A) Representative images of cleaved caspase-3 staining in brains from control and Sec24cNes-cKO mice at E11.5, E13.5, E16.5, and P0. Magnified areas from cortex (boxed area 1) and striatum (boxed area 2) are also shown. Scale bars: 500 μm (A) and 50 μm (A, insets). (B) Number (mean ± SEM) of caspase-3+ cells in the cortex and striatum in brains from control and Sec24cNes-cKO mice at E11.5, E13.5, E16.5, and P0. n = 3 for each genotype at each age. *P < 0.05, **P < 0.01, and ***P < 0.001, by Student’s t test.