Table 2.

Pooled weighted hazard ratios and 95% confidence intervals of stroke according to fish consumption

	No. of cohorts	No. of participants (events)	Fish consumption					Ptrend	Pinteraction
			<1/month	1–3/month	1/ week	2–4/week	≥5/week
All studies	19	402 127 (10 568)	1.0	0.97 (0.87–1.08)	0.86 (0.80–0.93)	0.91 (0.85–0.98)	0.87 (0.79–0.96)	0.09
Subtype of stroke
Ischemic stroke	11	311 106 (5406)	1.0	0.96 (0.84–1.11)	0.82 (0.73–0.93)	0.89 (0.81–0.97)	0.83 (0.75–0.92)	0.07	0.24
Hemorrhagic stroke	11	311 106 (1764)	1.0	1.08 (0.85–1.39)	0.96 (0.83–1.11)	0.97 (0.84–1.10)	0.92 (0.80–1.07)	0.28
Gender
Men	9	111 363 (4048)	1.0	0.96 (0.84–1.09)	0.89 (0.77–1.02)	0.93 (0.79–1.09)	0.90 (0.76–1.07)	0.16	0.19
Women	6	182 825 (3139)	1.0	1.00 (0.81–1.24)	0.83 (0.74–0.93)	0.88 (0.78–0.99)	0.74 (0.46–1.17)	0.09
Follow-up, year
<12.8	13	250 334 (5876)	1.0	0.98 (0.86–1.11)	0.85 (0.76–0.95)	0.92 (0.84–1.00)	0.88 (0.79–0.98)	0.11	0.57
≥12.8	6	151 793 (4692)	1.0	0.94 (0.76–1.18)	0.88 (0.78–0.99)	0.90 (0.78–1.04)	0.83 (0.67–1.02)	0.07
Location
Europe	7	83 381 (3023)	1.0	1.00 (0.77–1.29)	0.88 (0.75–1.03)	0.94 (0.80–1.11)	0.91 (0.76–1.08)	0.21	0.22
North	8	196 521 (4343)	1.0	0.97 (0.86–1.11)	0.86 (0.75–0.99)	0.87 (0.74–1.03)	0.79 (0.65–0.96)	0.03
America
Asia	4	122 225 (3202)	1.0	0.93 (0.72–1.21)	0.81 (0.69–0.95)	0.91 (0.82–1.00)	0.89 (0.72–1.10)	0.21
Dietary assessment
Interview-based	6	29 011 (1916)	1.0	0.95 (0.79–1.13)	0.94 (0.81–1.09)	0.90 (0.70–1.14)	1.05 (0.88–1.25)	0.95	0.12
Self-administered	13	373 116 (8652)	1.0	0.98 (0.86–1.12)	0.84 (0.77–0.92)	0.91 (0.86–0.97)	0.82 (0.75–0.91)	0.06
Stroke end point
Incidence	14	273 349 (8293)	1.0	0.95 (0.84–1.08)	0.86 (0.79–0.95)	0.88 (0.79–0.98)	0.83 (0.74–0.93)	0.047	0.18
Mortality	5	128 778 (2275)	1.0	1.02 (0.83–1.24)	0.85 (0.69–1.04)	0.95 (0.86–1.06)	0.97 (0.83–1.14)	0.40