TABLE 1.

Definition of the main parameters used in the model

${\text{Ca}}_{\mathrm{M}}^{2+}—\text{mitochondrial }(\text{matrix}){\text{ Ca}}^{2+}$

${\text{Ca}}_{\text{ext}}^{2+}—{\text{external Ca}}^{2+}$

M0—mitochondria (no Ca2+ added)

MCa—mitochondria with Ca2+

${\mathrm{M}}_{\text{Ca}}^{\mathrm{R}}—\text{mitochondria with reversible PTP}$

${\mathrm{M}}_{\text{Ca}}^{\text{Ir}}—\text{mitochondria with irreversible PTP}$

$\text{EGTA}+{\text{Ca}}_{\text{ext}}^{2+}—{\text{Ca}}^{2+}-\text{EGTA complex}$

k0—rate constant of “zero” swelling

k1—rate constant of Ca2+ uptake

k2—rate constant of PTP-independent Ca2+ release

k3—rate constant of reversible PTP-induced Ca2+ release

k4—rate constant of reversible swelling

k5—rate constant of irreversible swelling

k6—rate constant of Ca2+ sequestration by EGTA