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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Radiat Res. 2018 May 15;190(2):107–116. doi: 10.1667/RR15019.1

Figure 1.

Figure 1

Structures of (Z)-N,N′-bis[1-pyridin-2-yl-meth-(E)-ylidene]oct-4-ene-2,6-diyne-1,8-diamine (PyED) before and after complexation with Mg2+ (Mg2+-PyED), and (Z)-N,N′-bis[1-pyridin-2-yl-meth-(E)-ylidene]oct-4-ene-2,6-diyne-1,8-diamineplatinum(II) hexafluorophosphate (Pt-PyED). A. PyED; B. Mg2+-PyED; C. Pt-PyED. See Materials and Methods for syntheses of compounds. The metallation of PyED, a bis(pyridine)enediyne ligand, with Mg2+ occurs when it forms a Mg(II) complex upon dilution in cell culture medium (8,14).