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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Radiat Res. 2018 May 15;190(2):107–116. doi: 10.1667/RR15019.1

Figure 4.

Figure 4

Time-dependence of potentiation of cytotoxic effects of PyED with hyperthermia. U-1 cells were treated with either 50 μM PyED or DMSO (vehicle) for various times at 37 °C (A), 41.5 °C (B), and 42.5 °C (C). Surviving fractions were normalized to 0 min treatments where the cell monolayer was only washed with the treatment medium. Plating efficiencies were as follows: (A) 0.70 for cells treated with DMSO or 0.63 for cells treated with PyED at 37 °C, (B) 0.66 for cells treated with DMSO or 0.66 for cells treated with PyED at 41.5 °C, (C) 0.79 for cells treated with DMSO or 0.84 for cells treated with PyED at 42.5 °C. Error bars represent the SEM for 2 experiments.